Five structural modifications bring a substance within the definition
What the document says“``(A) By replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle. ``(B) By substitution in or on the phenethyl group with alkyl, alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino, or nitro groups. ``(C) By substitution in or on the piperidine ring with alkyl, alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, amino, or nitro groups.”
The first three of the five modifications listed in paragraph (2). The remaining two, not quoted here, are replacement of the aniline ring with any aromatic monocycle, whether or not further substituted in or on that ring, and replacement of the N-propionyl group with another acyl group. One modification is enough to bring a substance within the definition.
What the document actually says“``(A) By replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle. ``(B) By substitution in or on the phenethyl group with alkyl, alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino, or nitro groups. ``(C) By substitution in or on the piperidine ring with alkyl, alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, amino, or nitro groups.”
Here are three of the changes. One swaps a ring in the drug for a different ring. The other two add named atom groups to a ring or to a chain.
There are five changes in all. Just one of them is enough. A drug does not have to show all five.
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