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Executive Order 14355
Unlocking Cures for Pediatric Cancer With Artificial Intelligence
Signed September 30, 2025, printed at 90 FR 48153. 5 sections of substance, 1,065 words.
This order backs the use of AI against childhood cancer. It pools research data for that work.
Sec. 1. Purpose and Policy
My Administration is committed to driving innovation to prevent and treat childhood diseases, including through the use of artificial intelligence (AI). Pediatric cancer remains the leading cause of disease-related death for children in the United States aged 1-19 years, and its incidence has increased by more than 40 percent since 1975. As outlined in my joint address to the Congress in March, reversing this trend is one of the top priorities for the Make America Healthy Again (MAHA) Commission established in Executive Order 14212 of February 13, 2025 (Establishing the President's Make America Healthy Again Commission). AI presents an opportunity to more quickly achieve this aim. In 2019, my Administration created the Childhood Cancer Data Initiative (CCDI), a Federal investment in childhood cancer research of $50 million in funding every year for 10 years to address the critical need
My Administration is committed to driving innovation to prevent and treat childhood diseases, including through the use of artificial intelligence (AI). Pediatric cancer remains the leading cause of disease-related death for children in the United States aged 1-19 years, and its incidence has increased by more than 40 percent since 1975. As outlined in my joint address to the Congress in March, reversing this trend is one of the top priorities for the Make America Healthy Again (MAHA) Commission established in Executive Order 14212 of February 13, 2025 (Establishing the President's Make America Healthy Again Commission). AI presents an opportunity to more quickly achieve this aim. In 2019, my Administration created the Childhood Cancer Data Initiative (CCDI), a Federal investment in childhood cancer research of $50 million in funding every year for 10 years to address the critical need
This states the aim. It promises new work on childhood illness. AI is one tool named. It says cancer kills more children here than any other disease. The ages given are 1 to 19. It says cases are up more than 40 percent since 1975. It cites a health commission set up in February 2025. It recalls a 2019 data effort worth $50 million a year.
Sec. 2. Harnessing American AI Innovation
The MAHA Commission, in coordination with the Secretary of Health and Human Services (Secretary), the Assistant to the President for Science and Technology (APST), and the Special Advisor for AI and Crypto, and in alignment with the implementation of America's AI Action Plan, shall work to develop innovative ways to utilize advanced technologies such as AI to unlock improved diagnoses, treatments, cures, and prevention strategies for pediatric cancer. The initial focus shall be on identifying opportunities to accelerate the progress of AI-driven solutions at the CCDI, including by making data platforms and tools available as part of the CCDI Data Ecosystem and funding research projects at National Cancer Institute-Designated Cancer Centers that prioritize: (a) improving data infrastructure by consolidating data from multiple sources for AI-ready analysis and utilizing AI to better
The MAHA Commission, in coordination with the Secretary of Health and Human Services (Secretary), the Assistant to the President for Science and Technology (APST), and the Special Advisor for AI and Crypto, and in alignment with the implementation of America's AI Action Plan, shall work to develop innovative ways to utilize advanced technologies such as AI to unlock improved diagnoses, treatments, cures, and prevention strategies for pediatric cancer. The initial focus shall be on identifying opportunities to accelerate the progress of AI-driven solutions at the CCDI, including by making data platforms and tools available as part of the CCDI Data Ecosystem and funding research projects at National Cancer Institute-Designated Cancer Centers that prioritize: (a) improving data infrastructure by consolidating data from multiple sources for AI-ready analysis and utilizing AI to better
This puts AI to work on the problem. A health commission leads. The health secretary joins. So do two White House aides. The aim is better diagnosis and treatment. Cures and prevention are named too. The first focus is the childhood cancer data effort. Data tools go into a shared system. Grants go to named cancer centers.
Sec. 3.
Increasing Investment and Engagement in Pediatric Cancer Research and Care Infrastructure. The MAHA Commission, in coordination with the Secretary, the Director of the Office of Management and Budget, the Director of the National Institutes of Health, and the APST, shall prioritize expanding pediatric cancer research and advancements in care by identifying and implementing strategies for: (a) increasing investment from existing Federal funds for the CCDI and other Federal Government initiatives that address pediatric cancer; and (b) encouraging the private sector to make use of the most advanced technologies to unlock cures for pediatric cancer, including those based on AI, to the maximum possible extent.
Increasing Investment and Engagement in Pediatric Cancer Research and Care Infrastructure. The MAHA Commission, in coordination with the Secretary, the Director of the Office of Management and Budget, the Director of the National Institutes of Health, and the APST, shall prioritize expanding pediatric cancer research and advancements in care by identifying and implementing strategies for: (a) increasing investment from existing Federal funds for the CCDI and other Federal Government initiatives that address pediatric cancer; and (b) encouraging the private sector to make use of the most advanced technologies to unlock cures for pediatric cancer, including those based on AI, to the maximum possible extent.
This is about money and outside help. The health commission leads again. The budget office joins. So does the health research agency. So does a science aide. They must find ways to spend more on childhood cancer. That money comes from funds already set aside. They must also urge firms to use the best tools. AI is named.
Sec. 4. Improving Data Sharing and Empowering Patients
The Secretary, in consultation with the APST, shall work to ensure that AI innovation is appropriately integrated into current work on interoperability to maximize the potential for electronic health record and claims data to inform private sector and academic research and clinical trial design, while ensuring that patients and parents control their health information. In addition, the Secretary shall work to finalize interoperability standards for patient data to be used with AI that appropriately account for structured and unstructured data and enable safe and privacy-compliant exchanges of data.
The Secretary, in consultation with the APST, shall work to ensure that AI innovation is appropriately integrated into current work on interoperability to maximize the potential for electronic health record and claims data to inform private sector and academic research and clinical trial design, while ensuring that patients and parents control their health information. In addition, the Secretary shall work to finalize interoperability standards for patient data to be used with AI that appropriately account for structured and unstructured data and enable safe and privacy-compliant exchanges of data.
This is about sharing data. The health secretary works with a science aide. Health records must work with AI. Claims data is covered too. That data can guide research and trials. Patients and parents keep control of their records. The secretary must finish standards for such sharing. Both neat and messy data must fit. Privacy rules still hold.
Sec. 5. Definition
For the purposes of this order, ``artificial intelligence'' or ``AI'' has the meaning set forth in 15 U.S.C. 9401(3).
For the purposes of this order, ``artificial intelligence'' or ``AI'' has the meaning set forth in 15 U.S.C. 9401(3).
This defines the term AI. It points to the meaning set in federal law.
Sec. 6. General Provisions
Every order carries this. It is not what the order does.
(a) Nothing in this order shall be construed to impair or otherwise affect: (i) the authority granted by law to an executive department or agency, or the head thereof; or (ii) the functions of the Director of the Office of Management and Budget relating to budgetary, administrative, or legislative proposals. (b) This order shall be implemented consistent with applicable law and subject to the availability of appropriations. (c) This order is not intended to, and does not, create any right or benefit, substantive or procedural, enforceable at law or in equity by any party against the United States, its departments, agencies, or entities, its officers, employees, or agents, or any other person. [[Page 48155]] (d) The costs for publication of this order shall be borne by the Department of Health and Human Services. <GRAPHIC(S) NOT AVAILABLE IN TIFF FORMAT> (Presidential Sig.) THE WHITE
(a) Nothing in this order shall be construed to impair or otherwise affect: (i) the authority granted by law to an executive department or agency, or the head thereof; or (ii) the functions of the Director of the Office of Management and Budget relating to budgetary, administrative, or legislative proposals. (b) This order shall be implemented consistent with applicable law and subject to the availability of appropriations. (c) This order is not intended to, and does not, create any right or benefit, substantive or procedural, enforceable at law or in equity by any party against the United States, its departments, agencies, or entities, its officers, employees, or agents, or any other person. [[Page 48155]] (d) The costs for publication of this order shall be borne by the Department of Health and Human Services. <GRAPHIC(S) NOT AVAILABLE IN TIFF FORMAT> (Presidential Sig.) THE WHITE
This is the closing clause that nearly every order carries. It says the order does not change what the law already allows. It also says no one can sue to enforce it.
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