Executive Order 14363

Launching the Genesis Mission

Signed November 24, 2025, printed at 90 FR 55035. 6 sections of substance, 2,111 words.

In plain English

This order starts a science program. It is called the Genesis Mission. It puts the Energy Department in charge. The aim is to use AI to speed up research.

Read it at the Federal Register →

Sec. 1. Purpose

From the founding of our Republic, scientific discovery and technological innovation have driven American progress and prosperity. Today, America is in a race for global technology dominance in the development of artificial intelligence (AI), an important frontier of scientific discovery and economic growth. To that end, my Administration has taken a number of actions to win that race, including issuing multiple Executive Orders and implementing America's AI Action Plan, which recognizes the need to invest in AI- enabled science to accelerate scientific advancement. In this pivotal moment, the challenges we face require a historic national effort, comparable in urgency and ambition to the Manhattan Project that was instrumental to our victory in World War II and was a critical basis for the foundation of the Department of Energy (DOE) and its national laboratories. This order launches

In plain English

This states the aim. It says science has driven progress here since the founding. It calls AI the current race for world lead. It says the administration has acted to win it. Orders and an AI plan are cited. It says the moment calls for a national effort. It compares that to the wartime atom bomb project. It launches a mission.

Sec. 2. Establishment of the Genesis Mission

(a) There is hereby established the Genesis Mission (Mission), a national effort to accelerate the application of AI for transformative scientific discovery focused on pressing national challenges. (b) The Secretary of Energy (Secretary) shall be responsible for implementing the Mission within DOE, consistent with the provisions of this order, including, as appropriate and authorized by law, setting priorities and ensuring that all DOE resources used for elements of the Mission are integrated into a secure, unified platform. The Secretary may designate a senior political appointee to oversee day-to-day operations of the Mission. (c) The Assistant to the President for Science and Technology (APST) shall provide general leadership of the Mission, including coordination of [[Page 55036]] participating executive departments and agencies (agencies) through the National Science and Technology

In plain English

This sets up the Genesis Mission. It is a national push to use AI in science. Pressing problems here come first. The energy secretary runs it inside that department. It sets priorities. It must fold department tools into one secure platform. It may name a senior aide to run daily work. A White House science aide leads across agencies.

Sec. 3. Operation of the American Science and Security Platform

(a) The Secretary shall establish and operate the American Science and Security Platform (Platform) to serve as the infrastructure for the Mission with the purpose of providing, in an integrated manner and to the maximum extent practicable and consistent with law: (i) high-performance computing resources, including DOE national laboratory supercomputers and secure cloud-based AI computing environments, capable of supporting large-scale model training, simulation, and inference; (ii) AI modeling and analysis frameworks, including AI agents to explore design spaces, evaluate experimental outcomes, and automate workflows; (iii) computational tools, including AI-enabled predictive models, simulation models, and design optimization tools; (iv) domain-specific foundation models across the range of scientific domains covered; (v) secure access to appropriate datasets, including proprietary,

In plain English

This builds the platform. The energy secretary must run it. It holds the tools the mission needs. Big computers come first. National lab machines are named. So are secure cloud systems. They must train and run large models. AI tools for analysis are included. So are models tuned to each field. So is safe access to data.

Sec. 4. Identification of National Science and Technology Challenges

(a) Within 60 days of the date of this order, the Secretary shall identify and submit to the APST a detailed list of at least 20 science and technology [[Page 55037]] challenges of national importance that the Secretary assesses to have potential to be addressed through the Mission and that span priority domains consistent with National Science and Technology Memorandum 2 of September 23, 2025, including: (i) advanced manufacturing; (ii) biotechnology; (iii) critical materials; (iv) nuclear fission and fusion energy; (v) quantum information science; and (vi) semiconductors and microelectronics. (b) Within 30 days of submission of the list described in subsection (a) of this section, the APST shall review the proposed list and, working with participating agency members of the NSTC, coordinate the development of an expanded list that can serve as the initial set of national science and

In plain English

This picks the problems to solve. The secretary has 60 days. It must list at least 20 science challenges. Each must matter to the country. Each must fit the mission. Advanced manufacturing is one field. So is biotechnology. So are critical materials. So is nuclear energy. So is quantum science. So are chips. A science aide then widens the list.

Sec. 5. Interagency Coordination and External Engagement

(a) The APST, through the NSTC, and with support from the Federal Chief Data Officer Council and the Chief AI Officer Council, shall convene relevant and interested agencies to: (i) assist participating agencies in aligning, to the extent permitted by law, their AI-related programs, datasets, and research and development activities with the objectives of the Mission in their respective areas of expertise, while avoiding duplication of effort across the Federal Government and promoting interoperability; (ii) identify data sources that may support the Mission's aim; (iii) develop a process and resourcing plan in coordination with participating agencies for integrating appropriate and available agency data and infrastructure into the Mission, to the extent permitted by law and subject to available appropriations, including methods under which all agencies contributing to the Mission are

In plain English

This links the agencies. A science aide convenes them. Two data and AI councils help. Agencies must line up their AI work with the mission. Duplicate effort must be avoided. Systems must work together. They must find data that could serve the mission. They must plan how to fold in that data. Funding and law set the limits.

Sec. 6. Evaluation and Reporting

(a) Within 1 year of the date of this order, and on an annual basis thereafter, the Secretary shall submit a report to the President, through the APST and the Director of the Office of Management and Budget, describing: (i) the Platform's operational status and capabilities; (ii) progress toward integration across DOE national laboratories and other participating Federal research partners, including shared access to computing resources, data infrastructure, and research facilities; (iii) the status of user engagement, including participation of student researchers and any related training; (iv) updates on research efforts and outcomes achieved, including measurable scientific advances, publications, and prototype technologies; (v) the scope and outcomes of public-private partnerships, including collaborative research projects and any technology transitions or commercialization

In plain English

This requires reports. The first is due in a year. More follow each year. They go to the President. A science aide and the budget office pass them on. Each covers how the platform runs. Each covers work shared across the labs. Each covers who uses it, students included. Each covers results and papers. Private partnerships are covered too.

Sec. 7. General Provisions

Every order carries this. It is not what the order does.

(a) Nothing in this order shall be construed to impair or otherwise affect: (i) the authority granted by law to an executive department or agency, or the head thereof; or (ii) the functions of the Director of the Office of Management and Budget relating to budgetary, administrative, or legislative proposals. (b) This order shall be implemented consistent with applicable law and subject to the availability of appropriations. (c) This order is not intended to, and does not, create any right or benefit, substantive or procedural, enforceable at law or in equity by any party [[Page 55039]] against the United States, its departments, agencies, or entities, its officers, employees, or agents, or any other person. (d) The costs for publication of this order shall be borne by the Department of Energy. <GRAPHIC(S) NOT AVAILABLE IN TIFF FORMAT> (Presidential Sig.) THE WHITE HOUSE, November 24,

In plain English

This is the closing clause that nearly every order carries. It says the order does not change what the law already allows. It also says no one can sue to enforce it.

How this order is quoted

Each section is quoted as the order prints it, under its own number and heading. Executive orders are United States government works and are not under copyright. Long sections are cut at a sentence and the whole order is a click away.